CHAIN announces the appointment of Dr Matthew Duchars as Chief Executive from the 1st of August 2022

Nottingham, UK- 22nd of July 2022- FOR IMMEDIATE RELEASE

CHAIN Biotechnology has strengthened its senior management team through the appointment of Dr Matthew Duchars.

Matthew is an experienced leader in vaccine development and manufacture with senior management roles at the Vaccine Manufacturing and Innovation Centre, Oxford (CEO), the Sabin Vaccine institute, Washington DC, USA (Senior Vice President, R&D) and with Emergent Biosolutions, Gaithersburg, MD, USA (Vice President, Product Development).  

CHAIN Biotech has developed an innovative CADDTM platform which is based on living gut bacteria that form part of the microbiome. The bacteria produce functional molecules in the lower gastrointestinal tract where they have a positive impact on the gut microbiome and mucosal health. Engineering biology is used to add additional therapeutic functionality through the expression of specific antigenic peptides, which makes the CADDTM platform ideally suited for oral vaccines.

Matthew will replace CHAIN’s founder Dr Edward Green as Chief Executive with a focus on further developing the CADDTM platform for oral vaccination. Edward will remain on the Board, and act as Chief Scientific Advisor.

Dr Matthew Duchars said:

“I am excited to join the CHAIN team. I am greatly impressed by their expertise and highly innovative CADDTM platform technology with the potential to develop effective oral vaccines. The company has done a great job securing several strategic partnerships that bring both credibility and help de-risk drug development and manufacture.”  

Dr Nel Moore, Chair of CHAIN Biotech, said:  

“We are delighted to welcome Matthew to CHAIN’s leadership team. Matthew brings a wealth of experience in vaccine development and manufacture that complements our strain engineering and microbiology skills. I look forward to working closely with Matthew to develop our technology for oral vaccine applications, bringing benefit to patients and building shareholder value.”

ENDS

For more information please contact:

Edward Green, CHAIN Biotech

T: +44 (0)775 3610798 | E: edward@chainbiotech.com

CHAIN announces a new collaboration with clinical researchers at the University of Oxford to develop superior oral vaccines for infectious diseases

Marlow, UK- 22nd of June 2022- FOR IMMEDIATE RELEASE

CHAIN Biotechnology and the University of Oxford plan to collaborate on a two-year project to develop a new type of vaccine to immunise against human rotavirus (HRV) infection. Ultimately, the aim is to prevent Childhood Diarrhoeal Disease in malnourished children and transform the lives of millions of families across the world.

Childhood Diarrhoeal Disease (CDD) is a global health problem affecting over 1.7 billion children every year and resulting in over 500,000 deaths, mainly in low-income countries. The most common cause of CDD is infection with human rotavirus (HRV). Oral vaccines that protect against HRV infection are available but relatively expensive, and difficult to transport and administer in remote areas as they need to be kept cold. Also, they are largely ineffective in undernourished children.

We aim to develop a superior oral vaccine for HRV that is simple, inexpensive, highly effective and overcomes oral vaccine challenges associated with antigen preservation, antigen delivery and immune stimulation. Our goal is to subvert the vaccine efficacy gap in low-income countries and combat vaccine inequality.

CHAIN Biotech has developed an innovative CADDTM platform for oral drug delivery, based on living gutbacteria with a long, safe history of use in humans and engineered to deliver specific therapeutic cargo to the lower gastrointestinal tract. The bacteria are delivered orally, in spore form, and travel intact through the stomach and small intestine until they reach the colon where they germinate. The bacterial cells then grow and produce candidate molecules impacting on the gut mucosa. The CADDTM platform can be used for oral vaccination through the expression of specific antigenic peptides.

In this project, CHAIN will engineer Clostridium to secrete antigenic peptides designed to provoke an immune response against HRV. The University will undertake pre-clinical evaluation. This work will be led by Dr Kelsey Jones, a Senior Clinical Research Fellow at the Kennedy Institute of Rheumatology, University of Oxford, and an Honorary Consultant Paediatric Gastroenterologist at Great Ormond Street Hospital. Dr Jones investigates the association between malnutrition, immunology, and poverty with pioneering research into the effect of undernutrition on the innate immune system in the gut.

The project is supported by a grant from Innovate UK’s Biomedical Catalyst programme. The Assessors felt ‘the project has good potential with a favourable risk-reward profile, addresses high unmet clinical need and that the technical solution was highly innovative. Overall, CHAIN’s oral vaccine platform was deemed very attractive for public finding adding to the UK’s leadership in the vaccine field.’

Dr Edward Green, Chief Executive of CHAIN Biotech, said:  

‘We are really excited about our new project with the Kennedy Institute and the potential to build on this collaboration to validate our oral vaccine candidates. The University has world class expertise and facilities that should accelerate the development of our novel microbiome therapeutics for a broad range of clinical indications including oncology.’

Professor Fiona Powrie FRS, Professor of Musculoskeletal Sciences and Director of the Kennedy Institute of Rheumatology, added:

‘We are delighted to partner with CHAIN Biotech in developing this innovative mucosal vaccine platform. The ability to use the CADD system to target delivery of antigens and other molecules to specific regions of the gastrointestinal tract has significant translational potential.’

ENDS

For more information please contact:

Edward Green, CHAIN Biotech

T: +44 (0)775 3610798 | E: edward@chainbiotech.com

Notes to Editor

About the Kennedy Institute

The Kennedy Institute of Rheumatology at the University of Oxford is a world-leading medical research centre.  Discovery research drives development of transformative therapies for chronic inflammatory and degenerative disease. Directed by Professor Fiona Powrie FRS, the Kennedy Institute has over 25 research groups working in the areas of immunity and microbiome, inflammation biology and tissue re-modelling and repair. Investigators at the Institute take a multidisciplinary approach incorporating molecular and cellular biology with analysis of disease models and interrogation of patient tissue samples.

For more information, please visit: Homepage — The Kennedy Institute of Rheumatology (ox.ac.uk)

 CHAIN has developed a platform technology called CADDTM for oral drug delivery based on living bacteria (known as live biotherapeutics).  CADDTM is unique, transformational with broad clinical applicability. US and EU patents describing the use of CADDTM to treat inflammatory bowel disease have recently been granted.

Marlow, UK – 7th May 2021 – FOR IMMEDIATE RELEASE

UK-based CHAIN Biotechnology (CHAIN) develops novel therapeutics based on living bacteria that have been engineered to deliver therapeutic cargo to the lower gastrointestinal (GI) tract. The lower GI tract is an area of major clinical importance, housing a large portion of the gut microbiome as well as providing access to the immune system via the gut mucosa.  

Drug delivery to the lower GI tract is difficult using conventional approaches and diseases associated with this organ can be devastating for patients.  CHAIN’s European patent (EP 3515429) and US patent (10,987,325) relate to the development of a living biotherapeutics for treating inflammatory bowel disease and colorectal cancer.

The therapeutic cargo is a metabolite called (R)-3-hydroxybutyrate or β-hydroxybutyrate (β -HB). This is the major ketone body produced in the liver and provides a circulating energy source for tissue in times of fasting or following prolonged exercise. It is also a highly dynamic molecule with strong anti-inflammatory and anti-oxidative stress properties.

The patents describe the use of engineered bacteria to both produce and deliver β -HB to the GI tract and dampen inflammation. Our clinical focus is ulcerative colitis, a chronic and debilitating disease resulting from inflammation of the colon.

CHAIN’s therapeutics are delivered orally, and the candidate molecules are secreted during bacterial cell growth in the lower GI tract impacting on both the microbiota and gut mucosa. Oral drug delivery, using a live biotherapeutic producing an anti-inflammatory compound in the gut, should provide a safe and more effective treatment and provide patients with better control over their treatment regime.  

Dr Edward Green, CEO of CHAIN Biotech, said:

“We are delighted to get our first patents awarded in two key territories. Delivery of anti-inflammatory metabolites to the gut mucosa in a controlled fashion supports a new and highly effective treatment for inflammatory bowel disease.  We are excited about the therapeutic potential of this innovative product to treat chronic inflammation in the lower GI and provide significant patient benefits.  CHAIN’s drug development platform is novel with broad clinical applicability. These patents validate our approach paving the way for a new class of immuno-modulatory therapeutics.”

ENDS

For more information please contact:

Edward Green, Chief Executive CHAIN

T: +44 (0)775 3610798 | E: edward.green@chainbiotech.com

About CHAIN Biotech

CHAIN Biotechnology is a pre-clinical microbiome therapeutics company based at MediCity Nottingham with a head office in Marlow. CHAIN develops oral vaccines with immunomodulatory properties targeting infectious disease, inflammation and oncology.

CHAIN’s Clostridium Assisted Drug Development platform (CADDTM) technology is based on a single, but highly effective, Clostridium bacterial strain that is engineered to deliver a specific therapeutic modality, whilst also secreting metabolites that play key roles in gut and immune system homeostasis. The engineered strains produce the therapeutics in situ during growth in the lower GI tract, impacting on the systemic and mucosal immune system.

The CADDTM platform supports oral drug delivery that is targeted and controllable. In addition, our live biotherapeutics can be manufactured easily and cost-effectively and are highly stable (no cold chain logistics). The technology overcomes many of the challenges associated with drug delivery and vaccination.

 For more information, please visit: https://www.chainbiotech.com

Oxford Vacmedix and CHAIN Biotech have signed Heads of Terms for a Collaboration Agreement to develop and commercialise oral vaccines targeting cancer & infectious disease

Marlow, UK – 4th January 2021 – FOR IMMEDIATE RELEASE

CHAIN Biotechnology (CHAIN), a UK-based microbiome therapeutics company, focused on the development of oral vaccines, announced today that Heads of Terms for a Collaboration Agreement have been signed with Oxford Vacmedix (OVM).

The collaboration builds on a successful Innovate UK funded research programme between CHAIN and the University of Oxford using OVM’s recombinant overlapping peptide (ROP) vaccines integrated into CHAIN’s CADDTM oral drug technology based on engineered bacteria. The project results show that an ROP antigen designed for human papilloma virus (HPV) was successfully administered orally in mice using the CADDTM delivery system and that it stimulated an antigen specific systemic CD4+ and CD8+ T cell response via the gut mucosa.


The Collaboration Agreement is structured for OVM and CHAIN to co-develop a specific oral therapeutic vaccine for HPV and other oral vaccines targeting infectious disease and cancer. The benefits of oral delivery are compelling for the patient, with greater acceptability and ease of use with no injection related side effects. Oral vaccines based on CADDTM do not require any cold chain logistics and are relatively simple to manufacture. This reduces cost and supports widespread distribution. Furthermore, CADDTM oral vaccines can potentially stimulate a mucosal immune response at the site of infection offering improved efficacy.


Edward Green, CEO of CHAIN Biotech, said:
“We are delighted to be able to carry on the work started with the University of Oxford using an Innovate UK grant. This Agreement is our first external development partnership to exploit our innovative CADDTM oral drug delivery platform. We are excited about the therapeutic potential of OVM’s ROP technology and look forward to working together to develop novel oral vaccines that provide significant patient benefits”

William Finch, CEO of Oxford Vacmedix, added:
“We are very pleased to have signed these Heads of Terms for the Collaboration Agreement with CHAIN. The potential for effective vaccines that can easily be taken by mouth is enormous. If successful this development programme could lead to a new generation of orally delivered vaccines in cancer and potentially also in infectious diseases”

ENDS

For more information or to arrange an interview, please contact:
Edward Green, Chief Executive CHAIN
T: +44 (0)775 3610798 | E: edward.green@chainbiotech.com

Notes to Editor:
About CHAIN Biotech

CHAIN Biotechnology is a microbiome therapeutics company based at MediCity Nottingham with a head office in Marlow. CHAIN develops oral vaccines and immuno-therapies targeting the lower gastrointestinal tract with several therapeutic candidates in pre-clinical development.
CHAIN’s Clostridium Assisted Drug Development platform (CADDTM) technology is based on a single, but highly effective, Clostridium bacterial strain that is engineered to deliver a specific therapeutic modality, whilst also secreting metabolites that play key roles in gut and immune system homeostasis. The engineered strains produce the therapeutics in situ during growth in the lower gastrointestinal tract, impacting on the systemic and mucosal immune system.
The CADDTM platform supports oral drug delivery that is targeted and controllable. In addition, our live biotherapeutics can be manufactured easily and cost-effectively and are highly stable (no cold chain logistics). The technology overcomes many of the challenges associated with drug delivery and vaccination.
For more information, please visit: https://www.chainbiotech.com


About Oxford Vacmedix
Oxford Vacmedix UK Ltd, based on the Oxford Science Park, UK, is a bio-pharma company that utilizes the novel proprietary platform technology of recombinant overlapping peptides (ROPs) invented by Dr Shisong Jiang. ROPs have been validated as a technology to stimulate broad and strong T cell immunity therefore forming a good platform for cancer therapeutic vaccines and diagnostics. The company is a spin-out of the University of Oxford and has extensive contacts and collaborations in China through Changzhou Bioscience that is using the ROP platform in both diagnostics and adoptive cell therapy.
For more information, please visit: https://www.oxfordvacmedix.com

Following a 2-month closure, CHAIN reopened its laboratories in Nottingham on the 1st June. This comes after a risk assessment and change to working practices to maintain safe working for staff in the labs and office. MediCity has also implemented new measures in the building to support safe working practices which have also contributed to CHAIN staff being able to return to work.

Over the last 6 months, CHAIN has made considerable progress on validation and demonstration of its innovative Clostridium Assisted Drug Development platform (CADD), based on the use of engineered bacteria to deliver therapeutics to the colon. The Company can now progress key projects relating to vaccine development including a 2-year Innovate UK funded project focused on enteric pathogens including human rota virus.

The lockdown and lab closure has impacted operations, especially lab work. However, this period has also been highly productive, providing time to analyse recent results and modify our plans and research strategy accordingly. CHAIN will focus its efforts on vaccine development including a new Covid-19 vaccine project and build on recent proof of concept data to develop new projects in immuno-oncology. Our CADD platform is ideally suited for oral vaccination and immuno-modulation.

Going forward, CHAIN will continue to use video conferencing to maintain communication whilst minimising travel time. We will also retain flexible working conditions.

“I have been impressed by the team-work and camaraderie that has developed over the past few weeks through the use of video conferencing. In addition, our management team and Board have done a tremendous job supporting the business through this difficult time. I expect CHAIN to rebound strongly given our highly innovative technology platform and focus on diseases that are relevant and address significant unmet clinical needs”, said Dr Edward Green (CEO).

About CHAIN Biotechnology

CHAIN Biotechnology Ltd is a UK-based microbiome therapeutic company focused on the development and commercialisation of live medicinal products, a new class of drug based on living bacteria found in the gut but engineered to deliver specific therapeutic molecules. We specialise in engineering Clostridia bacteria and our proprietary technology platform (CADDTM), based on a single bacterial species, supports multiple therapeutic products. CHAIN’s products address unmet clinical needs for diseases associated with the human gut microbiome including inflammation, infection, and cancer.

CHAIN’s technology has the potential to transform healthcare across many chronic and debilitating diseases by providing, safer and more efficacious drugs delivered orally. CHAI’N’s live medicinal products do not require any cold chain logistics and easily scaled and cost-competitive to manufacture.

CHAIN was founded in 2014, by biotech entrepreneur Dr Edward Green and has labs at MediCity Nottingham with a head office in Marlow. CHAIN has assembled a highly experienced management team and Board comprising biotech and pharma leaders plus expert scientists with skills in microbiology, engineering biology and fermentation.

An Oxford based nutritional company, TdeltaS Ltd (TΔS®), has developed and commercialised a proprietary ketone ester, which can be used as a food to improve human physical performance and cognitive function in health and disease.  The Company’s product, ΔG®, is a ketone monoester that is marketed by HVMN Inc. in the USA for use in their sports drink for improved training, endurance performance and recovery following exercise.

CHAIN Biotech has engineered Clostridium bacteria to produce the chiral chemical building blocks needed to manufacture ΔG®.  CHAIN’s “chiral switch” technology supports a fermentation route to the chiral biochemicals, (R)-1,3 butanediol and (R)-3-hydroxybutyrate, from renewable sugar-based feedstocks.  The latter is a ‘ketone body’ produced naturally by the liver from fatty acids when fasting or through adopting a high fat ketogenic diet.

The partnership involves an 18-month project focusing on both strain and process improvements to optimise the manufacturing bioprocess and drive down the manufacturing costs of the chemical intermediates.  The aim is to deliver a robust fermentation bioprocess that supports a sustainable and cost-effective route to manufacture.

“I am delighted that we are working with Professor Kieran Clarke on this innovative nutritional product.  The project opens up new market opportunities for our bio-derived chiral chemicals and supports further development work on our microbiome therapeutics.  CHAIN will benefit from Kieran’s world leading expertise on (R)-3-hydroxybutyrate, a highly dynamic molecule with tremendous potential in a broad range of nutritional and therapeutic applications” said Dr Edward Green, Founder and Chief Executive, CHAIN Biotechnology Ltd.

“I am very excited to be starting this project with CHAIN Biotech, a company that has considerable expertise with Clostridia bacteria and unique skills in microbiology, engineering biology and fermentation.  CHAIN’s innovative and patented “chiral switch” technology supports cost-competitive production of the chiral building blocks we need to manufacture ΔG®.  Both companies share a vision around the nutritional and therapeutic benefits of (R)-3-hydroxybutyrate” said Professor Kieran Clarke, Founder and Chief Executive, TΔS® Ltd.

About CHAIN Biotechnology

CHAIN is a UK microbiome therapeutics company founded by biotech entrepreneur Dr Edward Green.  The team is based at MediCity, Nottingham, with a head office in Marlow.  CHAIN has built a proprietary and highly differentiated drug development platform (CADD™) based on a single, but highly effective, Clostridium strain.  The platform enables targeted, safe and controllable drug delivery to the colon.  CHAIN’s live biotherapeutic products have significant advantages, including ease of manufacture, low cost of goods and stability of the product.

CHAIN’s unique genetic engineering capability is used to add therapeutic functionality, with a platform that supports a pipeline of therapeutic candidates addressing multiple diseases associated with the human gut microbiome.  For example, CHAIN’s lead asset is a novel microbiome therapeutic based on an engineered Clostridium strain that produces and delivers (R)-3-hydroxybutyrate directly in the gut. We capitalise on the molecule’s anti-inflammatory properties targeting inflammatory bowel disease. More recently, the company has expanded its work to include vaccines and cancer therapies.

About TdeltaS (TΔS®)

TΔS® was founded in 2005 by Professor Kieran Clarke, Chair of Physiological Biochemistry at the University of Oxford.  Building on research at the University, the Company was established to develop and commercialise a proprietary ketone monoester, ΔG®, which can be used as a food to improve human physical performance and cognitive function in health and disease.  ΔG® is an entirely new food group offering great promise in a wide range of applications, from sports track to glycaemic control.  This revolutionary nutraceutical has shown great promise in sports drinks – for training, endurance performance and recovery following exercise. By directly influencing metabolic function, this new food group increases power output and decreases physical fatigue.  Human studies have been published in over 20 high-impact, peer-reviewed papers.

The synthesis and manufacture of ΔG® draws directly on pioneering research carried out at the University of Oxford and the National Institutes of Health. ΔG® is protected by a global patent and trademark portfolio.  Currently, ΔG® is marketed by HVMN Inc. in the USA in a sports drink that improves training, endurance performance and recovery following exercise.

CHAIN is pleased to announce a new 18-month research collaboration with Associate Professor John Heap and his research group at the University of Nottingham.

 

 

Dr Heap is Associate Professor of Synthetic Biology in the School of Life Sciences at the University of Nottingham, where he is also part of the newly-formed Biodiscovery Institute and the Green Chemicals Beacon.

John has a background in synthetic biology and metabolic engineering. His research group studies the use of natural and engineered metabolism for sustainable biomanufacturing, particularly using unconventional microorganisms with ‘exotic’ metabolic capabilities. The group’s research often involves developing and applying synthetic biology technologies to unlock the potential of these organisms, improve production of valuable chemicals, and enhance other industrially relevant properties.

John moved to the University of Nottingham from Imperial College London in 2019. At Imperial John was a Senior Lecturer in Synthetic Biology in the Department of Life Sciences and his group was based in the Imperial College Centre for Synthetic Biology. Prior to 2011, John undertook his PhD and first postdoctoral research position at the University of Nottingham, where he developed breakthrough genetic tools for industrially and medically important Clostridium bacteria. These include the widely used gene editing methods ACE and ClosTron.

“I am delighted that we are working with the Heap lab. John has world leading expertise engineering Clostridium and developed many of the tools that we currently use.  Together, we will apply our expertise and capabilities in engineering biology to deliver new functionality to our novel microbiome therapeutic platform. Our focus initially will be on metabolite production including β-hydroxy-butyrate. This new collaboration builds on a long-standing relationship with the University of Nottingham involving collaborations with the Synthetic Biology Research Centre and the School of Medicine” said Dr Edward Green, Chief Executive, CHAIN Biotechnology Ltd.

“I am very pleased to be starting this exciting project with CHAIN Biotech. Metabolic engineering of Clostridium enabled by synthetic biology approaches is a long-standing interest of ours, so it’s great to tackle such industrially relevant challenges. CHAIN’s established platform, team and route to market make this a perfect match.’’ said Dr John Heap.

 

About CHAIN

 

CHAIN Biotechnology is a UK microbiome therapeutics company founded by biotech entrepreneur Dr Edward Green. The team is based at MediCity, Nottingham with a head office in Marlow, Bucks.

CHAIN has built a proprietary and highly differentiated drug development platform (CADD™) based on a single, but highly effective, Clostridium strain. This platform enables targeted, safe and controllable drug delivery to the colon. CHAIN’s live biotherapeutic products also offer significant advantages including ease of manufacture, low cost of goods and stability of the drug product.  CHAIN’s unique genetic engineering capability is used to add therapeutic functionality and the platform supports a pipeline of therapeutic candidates addressing multiple diseases associated with the human gut microbiome. These include inflammatory bowel disease but more recently the company has expanded its work to include vaccines and cancer therapies.

 

About the University of Nottingham

 

The University of Nottingham is a research-intensive university with a proud heritage, consistently ranked among the world’s top 100. Studying at the University of Nottingham is a life-changing experience and we pride ourselves on unlocking the potential of our 44,000 students – Nottingham was named both Sports and International University of the Year in the 2019 Times and Sunday Times Good University Guide, was awarded gold in the TEF 2017 and features in the top 25 of all three major UK rankings. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia – part of a globally connected network of education, research and industrial engagement. We are ranked eighth for research power in the UK according to REF 2014. We have six beacons of research excellence helping to transform lives and change the world; we are also a major employer, proud of our Athena SWAN silver award, and a key industry partner- locally and globally.

Andrew has had a distinguished career at Danisco/DuPont, acting as Chief Scientific Officer (2008–2011) for Danisco and Chief Scientist for DuPont Nutrition & Health (2011–2019).  He was appointed a DuPont Fellow in 2016 and played a key role in helping build DuPont’s microbiome platform. 

 

 

Having retired from DuPont at the end of 2019, Andrew now chairs the UK’s KTN Microbiome Special Interest Group, which aims to raise the visibility and impact of the UK’s world leading microbiome science.

Andrew has a first-class honours degree in Biochemistry and a Doctorate in Microbial Biochemistry & Genetics from the University of Sussex.

“I am delighted that Andrew has joined the team. He brings 40 years’ experience in biosciences innovation in major global science-based companies spanning nutrition, health and agri-food. CHAIN’s microbiome platform technology has broad clinical applicability and we look forward to working with Andrew to develop new therapeutic opportunities and build new strategic partnerships with biotech and pharma. Andrew’s experience in microbial sciences should prove invaluable’’ said Dr Edward Green, Chief Executive, CHAIN Biotechnology Ltd.

“I am extremely pleased to be joining CHAIN Biotech as chief scientific adviser. CHAIN has a unique and impressive technology platform for the development of live medicinal products that combines leading capabilities in Clostridia engineering biology with microbiome science. I believe this has the potential to be a breakthrough technology platform enabling a wide range of microbiome therapeutic applications’’ said Dr Andrew Morgan.

 

About CHAIN Biotechnology


CHAIN is a UK microbiome therapeutics company founded by biotech entrepreneur Dr Edward Green. The team is based at MediCity, Nottingham with a head office in Marlow, Bucks.

CHAIN has built a proprietary and highly differentiated drug development platform (CADD) based on a single, but highly effective, Clostridium strain. This platform enables targeted, safe and controllable drug delivery to the colon. CHAIN’s live biotherapeutic products also offer significant advantages including ease of manufacture, low cost of goods and stability of the drug product. 

CHAIN’s unique genetic engineering capability is used to add therapeutic functionality and the platform supports a pipeline of therapeutic candidates addressing multiple diseases associated with the human gut microbiome. These include inflammatory bowel disease but more recently the company has expanded its work to include vaccines and cancer therapies.

Oxford, UK – 2nd July 2019

Oxford Vacmedix UK Limited (OVM), the UK-based biopharma company focused on the development of cancer vaccines, announced today the award of an Innovate UK grant to CHAIN Biotechnology Ltd (CHAIN) and the University of Oxford to develop live biotherapeutics that support oral delivery for OVM’s recombinant overlapping peptide (ROP) cancer vaccines. The research will use CHAIN’s proprietary microbiome technology and the world-class research facilities in the University’s department of Oncology.

The project will initially focus on OVM-100 in a research project titled “Mucosal delivery of Clostridium spores encoding recombinant overlapping peptides (ROPs) of HPV antigen as therapeutic vaccines for cervical cancer”. This will bring together University of Oxford’s expertise and CHAIN’s innovative microbial delivery platform to establish the effectiveness of delivering ROPs to the colon for the treatment of cervical cancer.

Spun out from the University of Oxford, OVM holds an exclusive licence for the ROP technology. The technology uses the novel, proprietary platform of ROPs to design and develop therapeutic cancer vaccines and diagnostics with the potential for increased efficacy, lower costs, simpler regulatory pathways and synergy when used in combination with other immune-oncology agents. OVM is developing two cancer vaccines, OVM-100 and OVM-200, focusing on unmet clinical need. OVM-100 is an HPV vaccine targeted at cervical cancer. OVM-200 represents a new type of vaccine utilising survivin, a protein inhibitor of apoptosis, to target solid tumours.

Dr Shisong Jiang, Principal Investigator in the Department of Oncology and Founder of OVM, said:

“We are delighted to have this opportunity to work with CHAIN on this exciting project. The importance of effective and controlled delivery is key to the development of new cancer vaccine and we are very pleased to have support and funding from Innovate UK for this work on our immunotherapy cancer vaccines.”

Dr Edward Green, Chief Executive and Founder of CHAIN added:

“This project provides a further opportunity to exemplify our Clostridium-Assisted Drug Development (CADDTM) platform for targeted gut delivery of therapeutic peptides. We look forward to a successful collaboration with OVM and to establishing a combination approach that simplifies and accelerates the development of oral cancer vaccines providing significant patient benefits.”

For more information or to arrange an interview, please contact:
William Finch, CEO, Oxford Vacmedix
T: +44 (0) 1865 742087 | M: +44(0)7769 903711 | E: wfinch@oxfordvacmedix.com
https://www.oxfordvacmedix.com

About Oxford Vacmedix

Oxford Vacmedix UK Ltd, based on the Oxford Science Park, UK, is a bio-pharma company that utilizes the novel proprietary platform technology of recombinant overlapping peptides (ROPs) invented by Dr Shisong Jiang. ROPs have been validated as a technology to stimulate broad and strong T cell immunity therefore forming a good platform for cancer therapeutic vaccines and diagnostics. The company is a spin-out of the University of Oxford and has extensive contacts and collaborations in China through Changzhou Bioscience that is using the ROP platform in both diagnostics and adoptive cell therapy.

For more information, please visit: www.oxfordvacmedix.com/

 

About CHAIN Biotech

CHAIN Biotechnology Ltd is a UK-based microbiome therapeutic company focused on the development and commercialisation of live biotherapeutic products (LBPs). LBPs are a new class of drug based on living bacteria found in the gut but engineered to deliver specific therapeutic molecules. We specialise in engineering Clostridia bacteria and our proprietary technology platform (CADDTM), based on a single bacterial species, supports multiple therapeutic products. CHAIN’s products address unmet clinical needs for safer, more effective and lower cost drugs. Treatments for diseases associated with the human gut microbiome have the potential to transform healthcare across many chronic and debilitating diseases. CHAIN was founded in 2014, by biotech entrepreneur Dr Edward Green and has labs at MediCity Nottingham with a head office in Marlow. CHAIN has assembled a highly experienced management team and Board comprising biotech and pharma leaders plus expert scientists with skills in microbiology, engineering biology and fermentation.

For more information, please visit: https://chainbiotech.com

 

NOTTINGHAM, UK. — January 9th, 2019 — CHAIN has joined EuropaBio as a full member after placing runner-up in the Biotech SME Awards announced in November. As part of this membership, CHAIN gains access to EuropaBio’s network and will receive updates from working groups operating in diverse areas such as IP, regulatory policy and personalised medicine.

The awards ceremony in Brussels was held on December 3rd where MEP Paul Rübig, who sits on the Committee for Industry, Research and Energy, hosted the awards ceremony. CHAIN Chief Executive Dr Edward Green represented the company giving a presentation. On becoming a member of EuropaBio, Dr Green said, “CHAIN is delighted to be recognised by the EuropaBio SME Awards; we are an early stage UK-based microbiome therapeutics company, so recognition on the European stage is a big boost for us and validation of our innovative technology platform. We hope recognition will raise awareness of CHAIN’s novel and highly differentiated approach to use superior live biotherapeutics to treat chronic and debilitating gut related diseases.”

EuropaBio is the largest biotech advocacy group in Europe, with members including national biotech organisations like the UK’s BioIndustry Association, industry giants Merck and Bayer, and SMEs. EuropaBio are implementing an SME platform where companies can attend workshops and webinars dedicated to providing advice and helping their development.

Dr Edward Green (left) receives award from Paul Rübig MEP

Dr Edward Green (left) receives award from Paul Rübig MEP

About CHAIN:

 

CHAIN Biotechnology is a UK microbiome company focused on the development and commercialisation of microbial technology for the production and delivery of biotherapeutics to the gut. The company’s microbial technology has the potential to be highly disruptive both in terms of cost but also efficacy for the treatment and prevention of chronic and debilitating gut related diseases. CHAIN was founded in 2014 by serial entrepreneur Dr Edward Green. The Company has bases in Marlow (Head office) and MediCity Nottingham (Research Lab).

 

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CONTACT INFORMATION

Dr David Kirk
Senior Scientist, CHAIN Biotechnology Ltd
Phone Number: +44 (0) 115 784 0106
Email: david.kirk@chainbiotech.com