CHAIN develops engineered Live Biotherapeutic Products based on a Clostridium chassis. We target candidate molecules that impact on the gut barrier and mucosal immune system, resident gut microbes and other organs that can be reached via the gut through neural and immune signalling networks.

As we build our candidate pipeline, we are keen to work with partners who have proven therapeutic candidates and are looking for a mechanism to effectively deliver these to the lower GI tract.


Careers

Building a team of experts:

We are building a team of expert scientists and business specialists to develop the company into a global healthcare leader specialising in diseases that can be impacted via the gut mucosa. We seek talented individuals who value hard work and share our vision.

As our novel biotherapeutics progress towards the clinic, we are keen to hear from interested candidates with pre-clinical development and clinical translation expertise. Expertise in the human microbiome, immunology, synthetic biology, and regulatory affairs are also desirable. In addition, we are interested in experts who can help shape and manage the drug development process in our commercial operations.

CHAIN is committed to promoting equal opportunities in employment. The company offers a competitive compensation and benefits package. If you are interested in working for CHAIN, please contact info@chainbiotech.com


Vacancies

Senior Scientist (Immunologist)

Full time
Competitive Salary

We have an exciting new opportunity for an experienced Senior Scientist to join our R&D team in Nottingham supporting the pre-clinical evaluation and clinical translation of our immuno-modulatory live biotherapeutics (LBP’s). This role involves investigating the immunological response of novel candidates including both practical laboratory work and managing our relationships with academic collaborators and CRO’s.

Key areas of responsibility include, but are not limited to:

  • Taking a lead role in designing, and performing studies aimed at assessing the efficacy and safety of novel therapeutics.
  • Developing in-house techniques, analyses and problem solving to generate key data for drug development projects.
  • Interpreting data (own and from other team members/partners) to create and develop hypotheses, study designs, and/or methods
  • Providing technical & scientific input and guidance to help shape therapeutic project strategy; may take on project leadership activities as needed.
  • Effectively and proactively communicating study designs/plans, data, interpretations/hypotheses as well as potential next steps in an appropriate and timely manner (both verbal and written) with line manager, other team members and project teams.
  • Presenting company progress reports at relevant conferences.
  • Adopting a strong team-oriented and openly communicative approach to all activities, while working independently and proactively where appropriate

We are looking for an enthusiastic and highly motivated individual with a relevant life sciences degree/PhD plus significant subsequent experience, including relevant academic or industrial research in the fields of immunology and drug discovery.  Applicants must have experience delivering and interpreting a broad repertoire of in vitro (and in vivo) immunology studies and assays as well as experience of preclinical evaluation of immunomodulatory agents.

Candidates must have demonstrable strong and effective team and communication skills as well as flexibility in managing workloads across more than one activity and possess advanced problem-solving abilities.

Apply in writing with a CV and cover letter to info@chainbiotech.com

Closing Date Oct 31st 2020

Scientist (Fermentation) 

Full time
Competitive Salary

We have an exciting new opportunity for a Scientist to join our R&D team in Nottingham. This role involves lab-scale fermentation supporting the development of our bio-manufacturing process for spore-based live biotherapeutics. You will be expected to follow and refine Standard Operating Procedures for fermentation and spore purification.

 

Key areas of responsibility include, but are not limited to:

 

  • Operation of lab-scale bioreactors
  • Preparation of sterile media, buffers and reagents
  • Routine analytical methods (cell growth, metabolite and protein secretion)
  • Support smooth lab operations that help our team operate at maximum efficiency.
  • Accurately and concisely report experimental work to other team members
  • Maintain accurate records allowing for full traceability of any experimental data.

 

We are looking for an enthusiastic and highly motivated individual with a degree in Microbiology, Biotechnology or related subject and at least one year post graduate experience.  The candidate must have good laboratory skills including good aseptic technique and adopt a rigorous approach to experimental work and able to precisely follow SOP’S and laboratory protocols. In addition, the candidate should be familiar with the operation of a bench-scale bioreactors and methods to measure cell growth and metabolite/protein secretion. Experience working with anaerobic bacteria is desirable.

 

Candidates must have demonstrable strong and effective team and communication skills as well as flexibility in managing workloads across several activities. You will have a keen eye for detail, excellent time management and great organisational skills.

Apply in writing with a CV and cover letter to info@chainbiotech.com

Closing Date Oct 31st 2020

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